Federal grant · National Institutes of Health

INCLUDE Project: Transformative Research Awards for Down syndrome (R01 Clinical Trial Not Allowed)

Status
Open
Posted
May 12, 2026
Closes
Jun 15, 2028
Est. total funding
$3.0M
Award range
— – $500K
Expected awards
4
Opportunity number
RFA-OD-27-004
Who can apply

Eligible applicants

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

About this grant

The NIH INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE (INCLUDE) Project seeks to improve health and quality-of-life for individuals with Down syndrome. The purpose of this Notice of Funding Opportunity (NOFO) is to solicit Transformative Research Award applications to support individual scientists or groups of scientists proposing groundbreaking, exceptionally innovative, original, and/or unconventional research that has the potential to create new scientific paradigms, establish entirely new and improved clinical approaches, or develop transformative technologies related to Down syndrome. Applications are welcome in all topics relevant to Down syndrome-related research or its co-occurring conditions. No preliminary data are required. Projects must clearly demonstrate, based on the strength of the logic, a compelling potential to produce a major impact in research related to Down syndrome.

Instrument
Grant
Activity
Health
Assistance listings
93.121, 93.173, 93.233, 93.242, 93.310, 93.350, 93.351, 93.395, 93.837, 93.838, 93.839, 93.840, 93.846, 93.847, 93.855, 93.865, 93.866, 93.867, 93.879
Cost sharing
Not required
Last updated
May 12, 2026

From Grants.gov's public daily extract of Oct 25, 2026. Agency contacts, full eligibility and application packages are on Grants.gov; always confirm deadlines there before applying.

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